Week

Day

Agent

Dosage

1

1

Prednisone

1-2 mg/kg PO q12 hr and continued throughout tx

1

Vincristine

0.025 mg/kg IV

1

Cyclophosphamide

10 mg/kg PO, SQ

2

8

Vincristine

0.025 mg/kg IV

3

15

Vincristine

0.025 mg/kg IV

4

22

Vincristine

0.025 mg/kg IV

24

Cyclophosphamide

10 mg/kg PO, SQ

7

46

Cyclophosphamide

10 mg/kg PO, SQ

9

63

Prednisone

Gradually decrease dose to 0 over the next 4 wk

Note: CBC should be checked weekly during therapy, after therapy is discontinued, continue to monitor CBC and physical exam q3months

Protocol 2

1

Vincristine

0.025 mg/kg IV

Asparaginase

400 IU/kg IP

Prednisone

1 mg/kg PO q24h and continued throughout therapy

2

Cyclophosphamide

10 mg/kg SQ

3

Doxyrubricin

1 mg/kg IV

4-6

As weeks 1-3 above,
but discontinue asparaginase

8

Vincristine

0.025 mg/kg IV

10

Cyclophosphamide

10 mg/kg SQ

12

Vincristine

0.025 mg/kg IV

14

Methotrexate

0.5 mg/kg IV

Note: protocol is continued in sequence biweekly after week 14, making the therapy protocol less intensive.

From: Carpenter's Exotic Animal Formulary, Third Edition, pg. 472, appendix 85